Cinnamoyl-coenzyme A is an intermediate in the phenylpropanoid metabolic pathway.

• Cinnamoyl-CoA reductase, an enzyme that catalyzes the chemical reaction cinnamaldehyde + CoA + NADP+ → cinnamoyl-CoA + NADPH + H+
• Pinosylvin synthase, an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + cinnamoyl-CoA → 4 CoA + pinosylvin + 4 CO₂
• Cinnamoyl-CoA:phenyllactate CoA-transferase, an enzyme that catalyzes the chemical reaction (E)-cinnamoyl-CoA + (R)-phenyllactate → (E)-cinnamate + (R)-phenyllactyl-CoA