Blow up, Blow-up or Blowup may refer to:

• Explosion
• Total body disruption, a cause of death typically associated with explosion
• An inflatable
• Blowing up, a mathematical operation
• Blowup, a 1966 film by Michelangelo Antonioni
• Blow-up and Other Stories, a short story collection by Julio Cortázar
• Blow Up (magazine), an Italy-based music magazine
• Blow Up (Dutch TV series)
  • Blow Up (Australian TV series), Australian adaptation of the Dutch television series
• Blow Up (French TV series)

• Blow Up (band), a British indie band
• Blow Up (club), a nightclub in Munich, established in 1967
• Blow Up (club night), a club night in London, established in 1993
• Blow Up (Bobby Hutcherson album), 1969
• Blow Up (The Smithereens album), 1991
• Blow-Up (soundtrack), an album by Herbie Hancock, featuring music composed for the 1966 film
• Blow Up (EP), a 2004 EP by The Presets
• Blow Up, an album by Bomba Estéreo
• Blow Up Records, a UK record label
• Blow Up, a song by Devo from the album "Total Devo"
• Blow Up, a song by Sammy Adams

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• Blow Out, a 1981 film by Brian De Palma