The 2020–21 Women's LEN Trophy is the 21st edition of the European second-tier tournament for women's water polo clubs. It was a Final Four that was played in Barcelona, Spain, on the 17 and 18 April 2021. Kinef Kirishi of Russia won its first LEN Trophy, beating CN Mataró of Spain 10–8 in the Final.^[1][2][3]

The participants were the four teams eliminated from the Euro League's quarterfinals.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Kinef-Surgutneftegas	23–24	Dynamo Uralochka	8–11	10–7 (5–6 p)
Astrapool Sabadell	19–22	Olympiacos	14–12	5–10
CN Mataró	18–21	UVSE Hunguest Hotel	9–12	9–9
Lifebrain SIS Roma	17–21	Dunaújváros	11–11	6–10

Final 4
Kinef Kirishi
Astrapool Sabadell
CN Mataró
Lifebrain SIS Roma

The referees for the Final Four were: Varkony (HUN), Markopoulou (GRE), Schwartz (ISR), Ohme (GER).^[4]

	Semi finals				Final
	30 April
	CN Mataró	9
					1 May
	Lifebrain SIS Roma	6
					CN Mataró	8
	30 April
					Kinef Kirishi	10
	Kinef Kirishi	18
	Astrapool Sabadell	12
					Third place
					1 May
					Lifebrain SIS Roma	5
					Astrapool Sabadell	11

17 April 2021 10:30	CN Mataró	9–6	Lifebrain SIS Roma	Barcelona, Spain
	Score by quarters: 1–1, 2–1, 3–2, 3–2
	Espar 6	Goals	Picozzi 2

17 April 2021 13:00	Kinef Kirishi	18–12	Astrapool Sabadell	Barcelona, Spain
	Score by quarters: 4–2, 4–3, 5–3, 5–4
	Keuning 6	Goals	three players 3

18 April 2021 10:15	Lifebrain SIS Roma	5–11	Astrapool Sabadell	Barcelona, Spain
	Score by quarters: 1–2, 1–3, 1–2, 2–4
	Avegno 3	Goals	Cordobes, Keuning 3

18 April 2021 13:00	CN Mataró	8–10	Kinef Kirishi	Barcelona, Spain
	Score by quarters: 0–1, 4–2, 3–2, 3–3
	Espar 4	Goals	Prokofyeva 3

• 2020–21 LEN Euro League Women