Defending champion Roger Federer defeated Lleyton Hewitt in the final, 6–2, 6–4, 6–4, to win the men's singles tennis title at the 2005 Indian Wells Masters. Federer did not lose a single set during the tournament.

All thirty-two seeds received a bye to the second round.

	Quarterfinals							Semifinals							Final
	1	Roger Federer	6	6
	29	Nicolas Kiefer	4	1
								1	Roger Federer	6	6
								14	Guillermo Cañas	3	1
	14	Guillermo Cañas	77	7
	6	Tim Henman	61	5
															1	Roger Federer	6	6	6
															2	Lleyton Hewitt	2	4	4
	7	Carlos Moyá	77	4	1
	3	Andy Roddick	64	6	6
								3	Andy Roddick	62	77	64
								2	Lleyton Hewitt	77	63	77
	9	Andre Agassi
	2	Lleyton Hewitt	w/o

	First round							Second round							Third round							Fourth round
								1	R Federer	6	6
		J-M Gambill	2	2					M Fish	3	3
		M Fish	6	6											1	R Federer	6	6
	Q	J-R Lisnard	4	5												G Müller	3	2
		G Müller	6	7					G Müller	6	3	6
								25	R Štěpánek	3	6	0
																						1	R Federer	77	77
																						13	I Ljubičić	63	64
								19	M Ančić	5	6	2
		H Arazi	1	1					T Berdych	7	3	6
		T Berdych	6	6												T Berdych	4	1
		F Volandri	1	4											13	I Ljubičić	6	6
	Q	T Zíb	6	6				Q	T Zíb	3	2
								13	I Ljubičić	6	6

	First round							Second round							Third round							Fourth round
								10	D Nalbandian	6	6
		A Dupuis	2	2					J Mónaco	2	1
		J Mónaco	6	6											10	D Nalbandian	6	3	6
		J Björkman	6	77												J Björkman	1	6	1
		I Labadze	1	64					J Björkman	4	6	77
								23	T Johansson	6	3	60
																						10	D Nalbandian	1	3
																						29	N Kiefer	6	6
								29	N Kiefer	6	6
		S Sargsian	6	6					S Sargsian	0	0
	Q	B Reynolds	3	2											29	N Kiefer	6	6
		M Mirnyi	6	4	77										8	G Gaudio	3	1
		X Malisse	3	6	64				M Mirnyi	77	3	64
								8	G Gaudio	65	6	77

	First round							Second round							Third round							Fourth round
								4	M Safin	4	6	7
		J Nieminen	6	77					J Nieminen	6	1	5
		L Horna	0	61											4	M Safin	5	4
		C Saulnier	6	6											30	T Dent	7	6
		V Hănescu	2	2					C Saulnier	6	61	2
								30	T Dent	1	77	6
																						30	T Dent	3	r
																						14	G Cañas	6
								22	J I Chela	64	6	6
	WC	A Kuznetsov	4	3					R Schüttler	77	4	1
		R Schüttler	6	6											22	J I Chela	5	6	4
		F Mayer	5	3											14	G Cañas	7	2	6
		K Carlsen	7	6					K Carlsen	4	3
								14	G Cañas	6	6

	First round							Second round							Third round							Fourth round
								12	T Robredo	6	6
		J Morrison	5	4				WC	G Monfils	3	1
	WC	G Monfils	7	6											12	T Robredo	4	6	77
		K Beck	0	5												T Enqvist	6	2	64
		T Enqvist	6	7					T Enqvist	6	6
								18	M Youzhny	4	1
																						12	T Robredo	4	6	2
																						6	T Henman	6	2	6
								32	J Melzer	77	3	6
	Q	P Goldstein	6	77				Q	P Goldstein	63	6	3
		H-T Lee	1	61											32	J Melzer	5	4
	Q	A Clément	6	6											6	T Henman	7	6
	WC	D Young	3	2				Q	A Clément	6	4	3
								6	T Henman	4	6	6

	First round							Second round							Third round							Fourth round
								7	C Moyá	6	6
		J C Ferrero	6	6					J C Ferrero	3	4
		I Andreev	3	3											7	C Moyá	6	6
	Q	B Vahaly	4	3												D Ferrer	3	4
		D Ferrer	6	6					D Ferrer	6	3	6
								27	S Grosjean	2	6	1
																						7	C Moyá	7	6
																							F Santoro	5	2
								24	F López	64	6	6
		I Karlović	77	6					I Karlović	77	4	4
		J Benneteau	62	4											24	F López	4	2
		F Santoro	6	6												F Santoro	6	6
		R Mello	2	3					F Santoro	4	6	78
								11	J Johansson	6	2	66

	First round							Second round							Third round							Fourth round
								15	N Davydenko	3	66
	WC	J Blake	6	6				WC	J Blake	6	78
		A Martín	2	3											WC	J Blake	4	6	3
		G Rusedski	3	7	6										17	F González	6	0	6
	Q	J Salzenstein	6	5	3				G Rusedski	64	65
								17	F González	77	77
																						17	F González	4	3
																						3	A Roddick	6	6
								26	J Novák	6	6
		M Zabaleta	5	4					O Rochus	3	4
		O Rochus	7	6											26	J Novák	1	2
	Q	W Odesnik	60	4											3	A Roddick	6	6
		F Verdasco	77	6					F Verdasco	3	6	62
								3	A Roddick	6	3	77

	First round							Second round							Third round							Fourth round
								5	G Coria	77	77
	Q	G Lapentti	5	1					K Kim	62	63
		K Kim	7	6											5	G Coria	6	6
		D Tursunov	2	6	3										31	P Srichaphan	4	2
		A Calleri	6	3	6				A Calleri	5	4
								31	P Srichaphan	7	6
																						5	G Coria	4	1
																						9	A Agassi	6	6
								21	A Pavel	65	78	6
	Q	G Carraz	79	6				Q	G Carraz	77	66	2
	WC	M Philippoussis	67	1											21	A Pavel	3	4
	Q	W Arthurs	6	6											9	A Agassi	6	6
		P Starace	4	3				Q	W Arthurs	4	1
								9	A Agassi	6	6

	First round							Second round							Third round							Fourth round
								16	T Haas	63	3
		Á Calatrava	3	6	1			PR	P-H Mathieu	77	6
	PR	P-H Mathieu	6	3	6										PR	P-H Mathieu	6	4	78
	Q	R Delgado	2	4												J Hernych	4	6	66
		J Hernych	6	6					J Hernych	6	1	78
								20	V Spadea	2	6	66
																						PR	P-H Mathieu	1	0
																						2	L Hewitt	6	6
								28	D Hrbatý	6	1	2
		M Llodra	6	6					M Llodra	4	6	6
	LL	D Sanguinetti	3	2												M Llodra	2	63
		J Acasuso	5	65											2	L Hewitt	6	77
		R Ginepri	7	77					R Ginepri	2	62
								2	L Hewitt	6	77

• 2005 Main Draw
• 2005 Qualifying Draw