Whole brain radiotherapy (WBRT) is a treatment option for patients with brain metastases. In WBRT, radiation therapy is administered broadly, to the whole brain, over multiple treatments.[1]

Usage

WBRT has been shown to alleviate symptoms, decrease the use of corticosteroids needed to control tumor-associated edema, and potentially improve overall survival.[2] However, WBRT has been reported to increase the risk of cognitive decline.[3]

WBRT may be administered in combination with stereotactic radiosurgery (SRS), surgery, or systemic therapies.[1] Based on data, WBRT combined with systemic therapies increased the likelihood of vomiting but overall, there were no other major differences regarding adverse events between these two treatment methods.[4] While these can improve survival for some patients with single brain metastasis, a 2021 systematic review of the literature found inconsistent results for overall survival.[1]

References

  1. ^ a b c Garsa A, Jang JK, Baxi S, Chen C, Akinniranye O, Hall O, et al. (2021). "Radiation Therapy for Brain Metastases". Effective Health Care (EHC) Program. Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health & Human Services. doi:10.23970/ahrqepccer242. PMID 34152714. S2CID 236256085.
  2. ^ McTyre E, Scott J, Chinnaiyan P (2013). "Whole brain radiotherapy for brain metastasis". Surgical Neurology International. 4 (Suppl 4): S236 – S244. doi:10.4103/2152-7806.111301. PMC 3656558. PMID 23717795.
  3. ^ Johnson K (June 2015). "Whole-Brain Radiotherapy: Risks Worth Benefit?". Medscape.com. Retrieved August 20, 2015.
  4. ^ Garsa A, Jang JK, Baxi S, Chen C, Akinniranye O, Hall O, et al. (2021-06-09). Radiation Therapy for Brain Metasases (Report). Agency for Healthcare Research and Quality (AHRQ). doi:10.23970/ahrqepccer242.
Allikas: https://en.wikipedia.org/wiki/Whole-brain_radiation
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