Sisto Gara della Rovere, also known as Sisto Franciotti della Rovere, (1473 – 8 March 1517) was an Italian Roman Catholic bishop and cardinal.

Sisto Gara della Rovere was born in Savona in 1473, the son of Gabriele Gara and Luchina Della Rovere, a member of the House of della Rovere.^[1] He was the nephew of Pope Julius II and the grand-nephew of Pope Sixtus IV.^[1] He was the half-brother of Cardinal Galeotto Franciotti della Rovere.^[1][2]

Pope Julius II made him a cardinal priest in the consistory of 11 September 1507.^[1][3] He received the red hat and the titular church of San Pietro in Vincoli on the same day.^[1] He also became Vice-Chancellor of the Holy Roman Church at this time, holding that office for the rest of his life.^[1]

The same day he became a cardinal, he was named apostolic administrator of the see of Lucca.^[1] He only resigned this post 5 days before his death.^[1] From 11 September 1507 until 11 June 1509 he was also administrator of the see of Vicenza.^[1] He was administrator of the metropolitan see of Benevento from 11 September 1508 to 6 March 1514.^[1] In 1508, he became Prior in Rome of the Sovereign Military Order of Malta.^[1]

He was elected Bishop of Padua on 11 June 1509 and subsequently occupied this see until his death.^[1] He was consecrated as a bishop by Cardinal Leonardo Grosso della Rovere in Rome on 25 November 1509.^[1]

He was also administrator of the see of Saluzzo from 27 September 1512 to 22 March 1516, though he filled this office through a vicar general, Antonio Vacca.^[1]

He participated in both the Fifth Council of the Lateran and in the papal conclave of 1513 that elected Pope Leo X.^[1]

He died in Rome on 8 March 1517.^[1] He was buried in San Pietro in Vincoli.^[1]