Samuel Shapiro may refer to:
- Samuel Shapiro (Illinois politician) (1907–1987), governor of Illinois
- Samuel Shapiro (Maine politician) (born 1927), Maine politician
- Shmuel Shapiro (born 1974), French Jewish rabbi, hazzan, and singer
- Samuel Sanford Shapiro (1930–2023), statistician who developed the Shapiro–Wilk test
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