SS City of Manchester may refer to various ships, including:^[1]

• SS City of Manchester (1851), a 2,109-gross register ton passenger liner launched in 1851 and wrecked in 1876
• SS City of Manchester (1851 wooden ship), a 534-ton wooden ship built in 1851 and sold 1860^[2] and in again 1863
• SS City of Manchester (1871), built in 1871 and lost off Ushant in 1885
• SS City of Manchester (1903), built in 1903 and scrapped in 1933
• SS City of Manchester (1935), built in 1935 and sunk 28 February 1942 by Japanese submarine I-153 off Java
• SS City of Manchester (1950), built in 1950, sold in 1971, and renamed Kavo Yerakes
• SS City of Manchester (1984), so named from 1984 and 1985, named Hassel Werder before and afterwards