A quarterback is a position in American and Canadian football.

Quarterback may also refer to:

• "Quarterback" (song), by Kira Isabella, 2014
• Quarterback (TV series), a 2023 streaming television series
• Quarterback (video game), a 1987 American football arcade game
• The Quarterback (1926 film), an American comedy silent film
• The Quarterback (1940 film), an American comedy film
• "The Quarterback" (Glee), a television episode
• Glee: The Quarterback, a 2013 EP by the cast of Glee