Mean Girls is a 2004 American film.

Mean Girls may also refer to:

• Mean Girls (2004 soundtrack)
• Mean Girls 2, a 2011 sequel to the 2004 film
• Mean Girls (musical), 2017, based on the 2004 film
• Mean Girls (2024 film), based on the musical
  • Mean Girls (2024 soundtrack)
• "Mean Girls", a 2024 song by Charli XCX from the album Brat

• Mean girl, the stereotype of a popular yet vindictive girl in high school
• "Mean Girl", a Status Quo song