The Lachnospiraceae are a family of obligately anaerobic, variably spore-forming bacteria in the order Eubacteriales that ferment diverse plant polysaccharides[3] to short-chain fatty acids (butyrate, acetate) and alcohols (ethanol). These bacteria are among the most abundant taxa in the rumen[4] and the human gut microbiota.[5][6][7][8] Members of this family may protect against colon cancer in humans by producing butyric acid.[9][10] Lachnospiraceae have been found to contribute to diabetes in genetically susceptible (ob/ob) germ-free mice.[11]

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[1] and National Center for Biotechnology Information (NCBI)[12]

16S rRNA based LTP_10_2024[13][14][15] 120 marker proteins based GTDB 09-RS220[16][17][18]
Lachnospiraceae
Lachnospiraceae

Catonella Moore & Moore 1994

"Ca. Caccomorpha" Gilroy et al. 2021

"Lachnoclostridium" Yutin & Galperin 2013

Eubacterium xylanophilum van Gylswyk & van der Toorn 1985

Jutongia Liu et al. 2022

Butyribacter Zou et al. 2021

Clostridium_AI

Velocimicrobium Wylensek et al. 2021

Anaerosporobacter Jeong et al. 2007

Mobilisporobacter Mbengue et al. 2016

Anaeromicropila Ueki et al. 2023

Mobilitalea Podosokorskaya et al. 2014[19]

Anaerocolumna Ueki et al. 2016

Coprococcus catus Holdeman & Moore 1974

Frisingicoccus Lagkouvardos et al. 2016

"Ca. Onthocola" Gilroy et al. 2021

"Ca. Scybalocola faecipullorum" Gilroy et al. 2021

Catenibacillus Braune & Blaut 2018

Eubacterium ruminantium Bryant 1959

"Wujia" Liu et al. 2021

Coprococcus Holdeman & Moore 1974

"Ca. Scybalomonas" Gilroy et al. 2021

Anaerobutyricum Shetty et al. 2018

"Ca. Fimousia" Gilroy et al. 2021

Anaerostipes Schwiertz et al. 2002

Bovifimicola Hitch et al. 2025

Parasporobacterium Lomans et al. 2004

Eubacterium_S & G

Eshraghiella Fatahi-Bafghi 2024

Falcatimonas Watanabe et al. 2016

Clostridium fimetarium Kotsyurbenko et al. 1997

Bacteroides pectinophilus Jensen & Canale-Parola 1987

Lachnospira Bryant & Small 1956

Anthropogastromicrobium Hitch et al. 2022

Cuneatibacter Lagkouvardos et al. 2016[20]

"Ca. Fimimorpha" Gilroy et al. 2021

"Ca. Pseudolachnospira" Glendinning et al. 2020

Hominifimenecus Afrizal et al. 2023

"Ca. Paralachnospira sangeri" Glendinning et al. 2020

Lientehia Abdugheni et al. 2023

"Ca. Avilachnospira" Gilroy et al. 2021

Oribacterium Carlier et al. 2004

Moryella Carlier, K'ouas & Han 2007

Johnsonella Moore & Moore 1994

Lachnoanaerobaculum Hedberg et al. 2012

Alitiscatomonas Hitch et al. 2022

"Ca. Copromonas" Gilroy et al. 2021 non Dobell 1908

"Ca. Ventrisoma" Gilroy et al. 2021

Clostridium_R

Otoolea Afrizal et al. 2023

Lachnoclostridium_A

"Ca. Caccovicinus" Gilroy et al. 2021

Enterocloster Haas & Blanchard 2020

Brotaphodocola Afrizal et al. 2023

"Ca. Hungatella pullicola" Gilroy et al. 2021

Hungatella Kaur et al. 2014

Lacrimispora Haas & Blanchard 2020

Acetitomaculum Greening & Leedle 1995[5]

Diplocloster Chaplin et al. 2022

Anaerosacchariphilus Kim et al. 2019

"Ca. Merdenecus" Gilroy et al. 2021

Anaerobium Patil et al. 2015

Lachnotalea Jarzembowska et al. 2016

Hominiventricola Afrizal et al. 2023

Laedolimicola Hitch et al. 2022

"Ca. Merdiplasma" Gilroy et al. 2021

"Ca. Choladousia Gilroy et al. 2021

Marvinbryantia Wolin et al. 2008

Muricoprocola Hitch et al. 2022

Murimonas Klaring et al. 2015

Robinsoniella Cotta et al. 2009

"Ca. Hominisplanchenecus murintestinalis" Afrizal et al. 2022

Hominisplanchenecus Afrizal et al. 2023

"Ca. Limivivens Gilroy et al. 2021

Shuttleworthella Deshmukh & Oren 2024 [Shuttleworthia[5]]

"Ca. Weimeria" Scarborough et al. 2020

"Ca. Pullilachnospira gallistercoris" Gilroy et al. 2021

Pararoseburia Abdugheni et al. 2022

Pseudobutyrivibrio van Gylswyk, Hippe & Rainey 1996

Eubacterium oxidoreducens corrig. Krumholz & Bryant 1986

Eubacterium ramulus Moore, Johnson &Holdeman 1976

Brotonthovivens Hitch et al. 2022

"Petralouisia" Afrizal et al. 2022

Eubacterium plexicaudatum Wilkins, Fulghum & Wilkins 1974

Roseburia_C

Roseburia zhanii Liu et al. 2022

Roseburia Stanton & Savage 1983

Lachnobacterium Whitford et al. 2001

"Roseburia porci" Wylensek et al. 2020

Agathobacter Rosero et al. 2016[21]

Butyrivibrio Bryant & Small 1956

Suilimivivens Hitch et al. 2021

Acetatifactor Pfeiffer et al. 2013

Kineothrix Haas & Blanchard 2017

Gallintestinimicrobium Hitch et al. 2022

Eisenbergiella Amir et al. 2014[22]

Suipraeoptans corrig. Wylensek et al. 2021

"Aequitasia" Vera-Ponce de Leon et al. 2022

Claveliimonas Hisatomi et al. 2023

Extibacter Lagkouvardos et al. 2017

Dorea Taras et al. 2002

Dorea hominis Liu et al. 2022

"Massilistercora" Tall et al. 2020

"Dorea phocaeensis" Takakura et al. 2019

Merdimonas Seo et al. 2017

Clostridium scindens Morris et al. 1985

Sporofaciens Rasmussen et al. 2021

Dorea_A

"Bariatricus" Bessis et al. 2016

Faecalimonas Sakamoto, Iino & Ohkuma 2017[23]

Sellimonas Seo et al. 2016

Hespellia Whitehead et al. 2004

Mediterraneibacter butyricigenes Kim et al. 2019

Ruminococcus_B

"Luxibacter" Naud et al. 2021

Muricomes Lagkouvardos et al. 2016 [incl. Faecalicatena[24]]

Schaedlerella Soh et al. 2019

Mediterraneibacter Togo et al. 2019

Porcincola Wylensek et al. 2021

Chordicoccus Gaffney et al. 2023

"Ca. Alectryocaccobium" Gilroy et al. 2021

Bilifractor Wylensek et al. 2021

"Ca. Scatomonas" Gilroy et al. 2021

Novisyntrophococcus Chai et al. 2021

Fusicatenibacter Takada et al. 2013

"Ca. Egerieimonas faecigallinarum" Gilroy et al. 2021

"Ca. Egerieimonas" Gilroy et al. 2021

"Ca. Pullilachnospira" Gilroy et al. 2021

Oliverpabstia Wylensek et al. 2021

Ruminococcus_G

Lactonifactor Clavel et al. 2007

Blautia Liu et al. 2008

Blautia_A

Unassinged Genera:

See also

References

  1. ^ a b J.P. Euzéby. "Lachnospiraceae". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2022-09-09.
  2. ^ "Family - L". List of Prokaryotic Names with Standing in Nomenclature. Retrieved 30 March 2021.
  3. ^ Boutard, M; Cerisy, T (13 November 2014). "Functional Diversity of Carbohydrate-Active Enzymes Enabling a Bacterium to Ferment Plant Biomass". PLOS Genetics. 10 (11): e1004773. doi:10.1371/journal.pgen.1004773. PMC 4230839. PMID 25393313.
  4. ^ Seshadri, R; Leahy, SC (19 March 2018). "Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection". Nature Biotechnology. 36 (4): 359–367. doi:10.1038/nbt.4110. PMC 6118326. PMID 29553575.
  5. ^ a b c d eol
  6. ^ Phyllis Kanki; Darrell Jay Grimes, eds. (2013). Infectious diseases selected entries from the Encyclopedia of sustainability science and technology. New York: Springer. ISBN 978-1-4614-5719-0.
  7. ^ UniProt
  8. ^ Paul De Vos; et al., eds. (2009). Bergey's manual of systematic bacteriology (2nd ed.). Dordrecht: Springer. ISBN 978-0-387-68489-5.
  9. ^ Meehan, C. J.; Beiko, R. G. (12 March 2014). "A Phylogenomic View of Ecological Specialization in the Lachnospiraceae, a Family of Digestive Tract-Associated Bacteria". Genome Biology and Evolution. 6 (3): 703–713. doi:10.1093/gbe/evu050. PMC 3971600. PMID 24625961.
  10. ^ Xia, Li C.; Liu, Gang; Gao, Yingxin; Li, Xiaoxin; Pan, Hongfei; Ai, Dongmei (2019). "Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model". Frontiers in Microbiology. 10: 826. doi:10.3389/fmicb.2019.00826. ISSN 1664-302X. PMC 6491826. PMID 31068913.
  11. ^ Kameyama, Keishi; Itoh, Kikuji (2014). "Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice". Microbes and Environments. 29 (4): 427–430. doi:10.1264/jsme2.ME14054. ISSN 1342-6311. PMC 4262368. PMID 25283478.
  12. ^ Sayers; et al. "Lachnospiraceae". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2022-09-09.
  13. ^ "The LTP". Retrieved 10 December 2024.
  14. ^ "LTP_all tree in newick format". Retrieved 10 December 2024.
  15. ^ "LTP_10_2024 Release Notes" (PDF). Retrieved 10 December 2024.
  16. ^ "GTDB release 09-RS220". Genome Taxonomy Database. Retrieved 10 May 2024.
  17. ^ "bac120_r220.sp_labels". Genome Taxonomy Database. Retrieved 10 May 2024.
  18. ^ "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2024.
  19. ^ UniProt
  20. ^ "Cuneatibacter". www.uniprot.org.
  21. ^ "Agathobacter". www.uniprot.org.
  22. ^ Parker, Charles Thomas; Garrity, George M (1 January 2003). Parker, Charles Thomas; Garrity, George M (eds.). "Taxonomic Abstract for the genera". The NamesforLife Abstracts. doi:10.1601/tx.25197.
  23. ^ Parker, Charles Thomas; Garrity, George M (2017). Parker, Charles Thomas; Garrity, George M (eds.). "Nomenclature Abstract for Faecalimonas Sakamoto et al. 2016". The NamesforLife Abstracts. doi:10.1601/nm.29877.
  24. ^ Parker, Charles Thomas; Garrity, George M (2017). Parker, Charles Thomas; Garrity, George M (eds.). "Nomenclature Abstract for Faecalicatena Sakamoto et al. 2016". The NamesforLife Abstracts. doi:10.1601/nm.29879.

Further reading

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