José A. Santos (born 1961) is a retired Chilean thoroughbred jockey.

Jose Santos or José Santos may also refer to:

• José Santos Becerra
• José Santos Chocano (1875–1934)
• José Santos González Vera (1897–1970), a Chilean anarchist writer
• José Santos Guardiola (1816–1862)
• José Santos Quinteros (1865–1951), a Bolivian lawyer, professor and politician
• José Santos Poyatos (born 1962), an athlete from Spain
• José Santos Ramírez (c. 1790–1851), an Argentine soldier
• Jose Santos Rios (1939–2018), a Northern Mariana Islands politician
• José Santos Romero (born 1951), an Argentine football manager and former player
• José Santos Salas (1888–1955), a Chilean physician and politician
• José Santos Valdés (born 1997), a Mexican sport shooter
• José Santos Zelaya (1853–1919), President of Nicaragua
• José Santos, a pseudonym of the American composer Lee Orean Smith