John Osborne (1929–1994) was an English playwright.

John Osborne may also refer to:

• John Osborne (broadcaster), radio DJ
• John Osborne (footballer) (1940–1998), English football goalkeeper
• John Eugene Osborne (1858–1943), American politician
• John Osborne, victim of one of the last duckings for witchcraft in England, murdered by Thomas Colley
• John Osborne (journalist) (1842–1908), Australian journalist and Methodist minister
• John Osborne (Montserrat politician) (1936–2011), Montserrat politician
  • John A. Osborne Airport in Montserrat, which is named for him
• John Osborne (Australian politician) (1878–1961), New South Wales politician
• John F. Osborne (1907–1981), American journalist and author, editor Time Life, New Republic
• John Osborne (Medal of Honor) (1844–1920), American sailor and Medal of Honor recipient
• John Osborne, 11th Duke of Leeds (1901–1963), British peer
• John Osborne (singer), part of the country duo Brothers Osborne
• John Osborne (writer) (born 1981), English writer and poet
• John Proby Osborne (1755–1787), Irish politician
• Sir John Osborne, 7th Baronet (1688–1743), Irish baronet, landowner and politician
• John Osborne (barrister) (1630s–1692), English barrister and judge
• John Walter Osborne (1828–1902), Irish-born Australian chemist and engineer
• John Osborne Jr. (1833–1922), British jockey
• John W. Osborne (1927–2019), American historian

• John Osborn (disambiguation)
• Ozzy Osbourne (born 1948), singer, real name John Osbourne