John F. Smith may refer to:

• John F. Smith (writer), American soap opera writer and producer
• John F. Smith Jr. (born 1938), American businessman
• Phenomenal Smith (John Francis Smith, 1864–1952), American baseball player
• John Frederick Smith (1806–1890), English novelist
• Ranger John Francis Smith, a fictional character
• John F. Smith (musician), British musician and trade unionist

• John Smith (disambiguation)