Factor X, or Coagulation factor X, is an enzyme.
Factor X may also refer to:
- Factor X (Chilean TV series), a version of The X Factor
- Factor X (Portuguese TV series), a version of The X Factor
- Factor X (Spanish TV series), a version of The X Factor
- El Factor X, the Colombian version of The X Factor
- Hemin, the "Factor X" required for the growth of Haemophilus influenzae
- “Factor X”, the motive of serial killer Dennis Rader
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