DPT may refer to:

• Dpt (unit) (dioptre/diopter), most commonly a unit measuring refraction and power in a lens or curved mirror
• Dermatopontin, a human extracellular matrix protein
• Dipropyltryptamine, a psychedelic tryptamine
• DPT vaccine, vaccine against diphtheria, pertussis and tetanus, also referred as DTP
• Doctor of Physical Therapy
• Distributed Processing Technology
• Dynamic Packet Transport

• Democratic Party of Turkmenistan
• Democratic peace theory, in political science
• Druk Phuensum Tshogpa, a political party in Bhutan

• Dumbarton People's Theatre, a Scottish theatre group
• Dirty Pretty Things (band), an English band founded in 2005
• Dirty Pretty Things (film), a 2002 British drama

• DPT, the National Rail station code for Devonport railway station, Devon, England
• Dublin Port Tunnel

• A department