Brian Murphy may refer to:

• Brian Murphy (Jamaican cricketer) (born 1973), Jamaican cricketer
• Brian Murphy (Zimbabwean cricketer) (born 1976), Zimbabwean cricketer
• Brian Murphy (baseball) (born 1980), American head baseball coach at the College of William & Mary
• Brian Murphy (Gaelic games) (born 1952), Irish former hurler and Gaelic footballer for Cork
• Brian Murphy (1990s Gaelic footballer), Irish former inter-county goalkeeper for Kerry and Dublin
• Brian Murphy (1960s Gaelic footballer) (born 1943), Irish former corner-back on the Cork senior football team
• Brian Murphy (Clonakilty Gaelic footballer) (born 1973), Irish Gaelic footballer
• Brian Murphy (hurler, born 1982) (born 1982), Irish former corner-back on the Cork senior hurling team
• Brian Murphy (ice hockey) (born 1947), played in one NHL game
• Brian Murphy (linesman), National Hockey League linesman, see 49th National Hockey League All-Star Game
• Brian Murphy (rugby union) (born 1985), Irish rugby player
• Brian Murphy (footballer, born 1983), Irish retired soccer player who was League of Ireland Goalkeeper of the Year 2008

• Brian Murphy (actor) (1932–2025), British actor most noted for his role as George Roper in the sitcom George and Mildred
• Brian Murphy (musician), Irish multi-instrumentalist and engineer
• Brian Murphy (politician) (born 1961), former mayor of Moncton in New Brunswick, Canada
• Brian Murphy (scholar) (1923–2017), Irish scholar of Russian literature
• Brian Murphy (writer) (born 1959), American religion editor for the Associated Press
• Brian K. Murphy (born 1985), American actor, producer, and writer
• Brian Murphy (1981–2000), Irish student killed unlawfully outside Club Anabel in Dublin (see Death of Brian Murphy)
• Brian Murphy (intelligence official), U.S. Federal agent who served as Under Secretary of Homeland Security for Intelligence and Analysis
• Brian R. Murphy (born 1942), American virologist

• Bryan Murphy (disambiguation)