Ayrshire Football Association or Ayrshire Football League or variation, may refer to:

• Ayrshire Football League (1891–1895; 1900–1901)
• Ayrshire Football Combination (1893–1897)
• Ayrshire and Renfrewshire Football League (1903–1905)
• Ayrshire Junior Football League (1919–2002)
• Ayrshire Amateur Football Association (est. 1935)