4-Hydroxy-5-methoxytryptamine (4-HO-5-MeO-T) is a serotonergic neurotoxin of the tryptamine family.[1][2] It is structurally related to the monoamine neurotransmitter serotonin (5-hydroxytryptamine; 5-HT).[2][1] The drug is also a monoamine reuptake inhibitor.[2][1] Its analogue 4,5-dihydroxytryptamine (4,5-DHT) is also a serotonergic neurotoxin.[2][1] Rapid auto-oxidation of 4-HO-5-MeO-T and 4,5-DHT prevents them from being used as serotonergic neurotoxins in scientific research.[2]

See also

References

  1. ^ a b c d Horn AS, Baumgarten HG, Schlosserberger HG (July 1973). "Inhibition of the uptake of 5-hydroxytryptamine, noradrenaline and dopamine into rat brain homogenates by various hydroxylated tryptamines". Journal of Neurochemistry. 21 (1): 233–236. doi:10.1111/j.1471-4159.1973.tb04242.x. PMID 4720899.
  2. ^ a b c d e Schlossberger HG (1978). "Synthesis and Chemical Properties of Some Indole Derivatives". Annals of the New York Academy of Sciences. 305 (1): 25–35. Bibcode:1978NYASA.305...25S. doi:10.1111/j.1749-6632.1978.tb31508.x. ISSN 0077-8923.
Allikas: https://en.wikipedia.org/wiki/4-Hydroxy-5-methoxytryptamine
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