Anna Chakvetadze defeated Nadia Petrova in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 Kremlin Cup.

Mary Pierce was the reigning champion, but did not compete this year.

A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top four seeds received a bye to the second round.

	Semifinals							Final
	8	Nicole Vaidišová	0	6	63
	5	Nadia Petrova	6	4	77
								5	Nadia Petrova	4	4
									Anna Chakvetadze	6	6
	4	Elena Dementieva	5	6	0
		Anna Chakvetadze	7	3	6

	First round							Second round							Quarterfinals							Semifinals
								1	A Mauresmo	5	6	77
		E Vesnina	6	1	713				E Vesnina	7	3	63
		N Li	2	6	611										1	A Mauresmo	6	5	63
		S Stosur	4	6	6										8	N Vaidišová	1	7	77
	Q	E Gagliardi	6	3	2				S Stosur	4	1
	WC	A Pavlyuchenkova	3	3				8	N Vaidišová	6	6
	8	N Vaidišová	6	6																		8	N Vaidišová	0	6	63
																						5	N Petrova	6	4	77
								3	S Kuznetsova	1	3
	WC	V Dushevina	3	2					V Zvonareva	6	6
		V Zvonareva	6	6												V Zvonareva	5	1
		E Likhovtseva	6	6											5	N Petrova	7	6
		ME Camerin	0	1					E Likhovtseva	3	5
		A-L Grönefeld	2	2				5	N Petrova	6	7
	5	N Petrova	6	6

	First round							Second round							Quarterfinals							Semifinals
	6	P Schnyder	6	6
		C Rubin	3	0				6	P Schnyder	77	1	6
	Q	I Benešová	3	6	7			Q	I Benešová	63	6	1
		M Santangelo	6	3	5										6	P Schnyder	66	61
		S Pe'er	6	6											4	E Dementieva	78	77
	WC	E Bovina	0	2					S Pe'er	6	63	3
								4	E Dementieva	4	77	6
																						4	E Dementieva	5	6	0
	7	D Safina	1	2																			A Chakvetadze	7	3	6
		A Chakvetadze	6	6					A Chakvetadze	77	6
		F Schiavone	3	7	77				F Schiavone	63	4
		M Kirilenko	6	5	63											A Chakvetadze	w/o
	Q	E Bychkova	6	6											2	M Sharapova
	Q	A Rodionova	3	4				Q	E Bychkova	4	5
								2	M Sharapova	6	7

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