Events from the year 1680 in Denmark.

• Monarch – Christian V^[1]
• Grand Chancellor – Frederik Ahlefeldt

• 26 October – Prince Charles of Denmark, prince of Denmark (died 1729)
• 20 November – Severin de Junge, Supreme Court justice and director of the Danish West India Company (died 1757)

• 28 November – Alexander Frederik Møsting, royal court official (died 1737)

• Rasmus Krag, naval officer (died 1755)

• 25 April – Simon Paulli, physician and naturalist (born 1603)
• 4 December – Thomas Bartholin, physician, mathematician, and theologian (born 1616)
• 29 December – Arent Berntsen, topographical-statistical author, businessman, banker, estate owner and councillor (born 1610)