The decade of the 1250s in art involved some significant events.

• 
  Duccio Maestà with Twenty Angels and Nineteen Saints

• c.1250: The doorway from Moutiers-Saint-Jean is carved
• 1250: The illuminated manuscript Morgan Bible is completed
• 1251: Kei school sculptor produces Tamayori-bime statue in Yoshino Mikumari Shrine
• 1251–1254: Tankei sculpts a Thousand-armed Kannon at Sanjūsangen-dō

• 1250: Giovanni Pisano, Italian sculptor, painter and architect (died 1315)
• 1254
  • Ren Renfa, Chinese painter of horses, people, flowers and birds (died 1327)
  • Zhao Mengfu, Chinese scholar, painter and calligrapher during the Yuan Dynasty (died 1322)
• c.1255
  • Duccio, Italian artist, influential in his time (died 1318/19)
  • Filippo Rusuti, Italian painter and mosaicist (died 1325)
• 1259: Pietro Cavallini, Italian painter and mosaic designer working during the late Middle Ages (died c.1330)

• 1256: Tankei, Japanese sculptor of the Kei school (born 1173)
• 1258: Giunta Pisano, Italian painter (born 1180)