VC10 or VC-10 may refer to:
- Vickers VC10, a British jet airliner
- VC-10 Challengers, a former United States Navy aircraft squadron
- Korg VC-10, an analogue vocoder from the 1970s
- Super VC-10 Hap, a species of fish
- MAX Machine, a home computer
- Akpeteshie, a Ghanaian spirit
- Visual C++ 2010, the 2010 edition of Microsoft Visual C++, a software integrated development environment
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