Scamandrius or Skamandrios (Ancient Greek: Σκαμάνδριος) may refer to:
- Astyanax, son of Hector and Andromache
- Helenus of Troy, son of Priam
- Scamandrius (Trojan War), a Trojan warrior.
- Skamandrios (moon), satellite of the asteroid 624 Hektor
- Scamandrius, eponymous archon 510–509 BC
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