St. Mary's College (CIC, which stands for College of the Immaculate Conception) is a government-assisted selective Catholic secondary school located in Port of Spain, Trinidad and Tobago.

• Ellis Achong, West Indies Test cricketer
• Emmanuel Amoroso, reproductive physiologist and developmental biologist
• Eugene Chen (1878–1944), Trinidadian-Chinese politician and foreign minister of Republic of China
• Ellis Clarke, first President of Trinidad and Tobago.
• Diego Cisneros, businessman
• Joshua Da Silva, West Indies Test cricketer
• Leslie Fitzpatrick, soccer player
• Angus Fraser (clergyman and teacher), founder of the Via Christi Society
• Wayne A.I. Frederick, President of Howard University
• Ken Gordon, businessman
• Shaka Hislop, football player
• Jillionaire, DJ and music producer
• John La Rose, publisher and cultural activist
• Clement Ligoure, physician and publisher
• Michael Mooleedhar, filmmaker
• Quintin O'Connor, union leader
• George Padmore (1903–1959), pan-Africanist, author
• Joseph Lennox Pawan, MBE, Trinidadian bacteriologist
• Clifford Roach, West Indies Test cricketer
• Harry Schachter, Canadian biochemist
• Stuart Young, Prime Minister-designate of Trinidad and Tobago

• Official website