OFM may refer to:

• Office of Foreign Missions, part of the US Department of State
• Officine Ferroviarie Meridionali, an Italian railway and rolling stock manufacturer
• OFM (South Africa), a radio station in Bloemfontein, South Africa
• Open flow microperfusion, a sampling method for clinical and preclinical drug development studies and biomarker research
• Office of the Fire Marshal of Ontario, a fire marshal office in Ontario, Canada
• Oracle Fusion Middleware, a company
• Orange Factory Music, a music production team
• Orthodox file manager, a text-menu based file manager

• Order of Friars Minor, a Franciscan religious order
• Order of Friars Minor Capuchin, a Franciscan religious order
• Order of Friars Minor Conventual, a Franciscan religious order