The Mellon National Bank Building at 500 Smithfield Street in downtown Pittsburgh, Pennsylvania, was completed in 1924 after Mellon acquired the property in August 1916 from the Baltimore & Ohio Railroad which had their regional offices on the site.^[3]

Prior to the B&O office the site was the original home to the city's first public high school (Central High), which opened in the fall of 1855.^[4] The Classical-styled building was designed by architects Trowbridge & Livingston with Edward Mellon. It was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 1976,^[2] and the List of City of Pittsburgh historic designations in July 1999.^[1]

On July 30, 1999, May & Co. bought the structure for $9.250 million from Mellon.^[5] The building's historic interior was gutted and converted into a department store despite the protests of historical preservationists. It opened as Lord & Taylor on November 1, 2000, after a $12 million refurbishment (21.9 million in 2024 dollars).^[6] Lord & Taylor closed just four years later, in 2004.

On May 31, 2012 PNC Financial Services purchased the structure^[7] and converted it to a call center.^[8] In 2024, PNC announced their intention to sell the building.^[9]

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