Mark Walker may refer to:

• Mark L. Walker (born 1941), member of the Illinois House of Representatives
• Mark Walker (North Carolina politician) (born 1969), minister and U.S. House of Representatives member for North Carolina's 6th District
• Mark Walker (Maine politician), member of the Maine House of Representatrives
• Mark W. Walker, member of the Utah House of Representatives
• Mark E. Walker (born 1967), United States federal judge in Florida

• Mark Walker (British Army officer) (1827–1902), Irish recipient of the Victoria Cross
• Mark Walker (entertainer), British cabaret and musical theatre entertainer; regular cast member of 1980s TV show, The Laughter Show
• Mark Walker (songwriter) (1846–1924), fisherman and songwriter
• Mark Alan Walker, professor of philosophy at New Mexico State University
• Mark H. Walker, writer and board wargame designer