Route 215 or Highway 215 may refer to:

• Buenos Aires Provincial Route 215

• Manitoba Provincial Road 215
• New Brunswick Route 215
• Nova Scotia Route 215
• Prince Edward Island Route 215
• Quebec Route 215

• Route 215-CH in Los Lagos Region

• China National Highway 215

• National Route 215

• R215 road (Ireland)

• Bundesautobahn 215 (A 215)
• Bundesstraße 215 (B 215)

• National Highway 215 (India)

• A215 road
• B215 road

• Interstate 215 (California)
• Interstate 215 (Nevada)
• Interstate 215 (Utah)
• Alabama State Route 215
• Arkansas Highway 215
• California State Route 215 (former)
• Clark County 215
• Florida State Road 215 (former)
• Georgia State Route 215
• Iowa Highway 215 (former)
• K-215 (Kansas highway)
• Kentucky Route 215
• Maine State Route 215
• M-215 (Michigan highway) (former)
• Missouri Route 215
• Montana Secondary Highway 215
• New Mexico State Road 215
• New York State Route 215
• North Carolina Highway 215
• Ohio State Route 215
• Oregon Route 215 (former)
• Pennsylvania Route 215
• South Carolina Highway 215
• Tennessee State Route 215
• Texas State Highway 215 (former)
  • Texas State Highway Spur 215
• Utah State Route 215 (former)
• Vermont Route 215
• Virginia State Route 215
• Washington State Route 215
• Wyoming Highway 215