John Burke may refer to:

• John mac Richard Mór Burke, 10th Clanricarde or Mac William Uachtar (died 1536), Irish chieftain and noble
• John Burke, 9th Earl of Clanricarde (1642–1722), Irish soldier and peer
• John Smith de Burgh, 11th Earl of Clanricarde or John Smith Burke (1720–1782), Irish peer
• John Burke, Baron Leitrim or John "na Seamer" Burke or Seán mac an Iarla a Búrc, 1st Baron Leitrim (died 1583), Irish noble
• Sir John Burke, 2nd Baronet (1782–1847), Irish soldier and MP for Galway County
• John Burke (North Dakota politician) (1859–1937), 10th Governor of North Dakota and Treasurer of the United States
  • John Burke (Fairbanks), a 1963 bronze sculpture
• John H. Burke (1894–1951), American lawyer, real estate broker, and politician
• John Francis Burke (1923–2006), Canadian politician
• John Burke (mayor) (born 1946), mayor of Porirua City New Zealand, 1983–1998
• John R. Burke (1924–1993), U.S. ambassador to Guyana
• John P. Burke (born 1954), American politician in Massachusetts
• John Burke (Rhode Island politician) (born 1960), member of the Rhode Island Senate

• John Burke (spy) (1830–1871), Confederate spy in the American Civil War
• John Burke (colonel) (1838–1914), officer in the Union Army during the American Civil War
• John Luddy Burke (1909–2003), United States Navy officer and business executive
• John Oge Burke (died 1601), Irish gentleman and soldier

• Johnny Burke (lyricist) (1908–1964), American songwriter
• John Burke (composer) (1951–2020), Canadian composer
• Johnny Burke (Newfoundland songwriter) (1851–1930), Newfoundland songwriter
• Johnny Burke (Canadian singer) (1940–2017), Canadian country singer
• John Burke (American pianist) (born 1988), American composer & pianist

• John Burke (1900s pitcher) (1877–1950), U.S. baseball player for the New York Giants
• John Burke (1990s pitcher) (born 1970), U.S. baseball player for the Colorado Rockies and the University of Florida
• John Burke (American football) (born 1971), played for the New England Patriots, New York Jets and San Diego Chargers
• John Burke (footballer, fl. 1927–1935), Irish footballer from Tipperary
• Johnny Burke (footballer) (1911–1987), Irish footballer
• John Burke (footballer, born 1956), Irish footballer from Dublin
• John Burke (footballer, born 1962), Scottish footballer for Exeter City and Chester City
• John Burke (rugby league, born 1948) (1948–2013), rugby league footballer of the 1970s for Leeds, Keighley
• John Burke (rugby league, born 1957), rugby league footballer of the 1970s for Wigan, and Workington Town
• Jack Burke Sr. (John Burke, 1888–1943), American golfer
• Jack Burke Jr. (John Burke, 1923–2024), American golfer

• John MacSeonin Burke, Archbishop of Tuam, 1441–1450
• John J. Burke (1875–1936), Paulist priest and editor of the Catholic World
• John Burke (genealogist) (1786–1848), Irish genealogist, founder of Burke's Peerage
• Sir John Bernard Burke (1814–1892), British genealogist
• John Edward Burke (1871–1947), shipowner in Queensland, Australia
• John F. Burke (1922–2011), American medical researcher and co-inventor of synthetic skin in 1981
• Arizona John Burke (1842–1917), American publicist, press agent and author
• John P. Burke (unionist) (1884–1966), American labor unionist and socialist politician
• John Burke (author) (1922–2011), English writer of novels and short stories
• John Burke (artist) (1946–2006), Irish artist
• John Burke (photographer) (c. 1843–1900), British photographer
• John M. Burke (born 2001), American chess player
• John Burke, president of Trek Bicycle Corporation
• SS John Burke, an American Liberty Ship destroyed in a kamikaze attack

• Jack Burke (disambiguation)
• John Bourke (disambiguation)