Irigoyen is a surname. Notable people with the surname include:

• Adam Irigoyen (born 1997), American actor
• Álvaro Arzú Irigoyen (1946–2018), Guatemalan politician, former President
• Bernardo de Irigoyen (1822–1906), Argentine lawyer, diplomat and politician
• Bernardo Irigoyen (born 1969), Argentine cricketer
• Elsa Irigoyen (1919–2001), Argentine fencer
• José Irigoyen (before 1797 – c. 1839), appointed Spanish governor of Texas who never arrived to claim his office
• Julio Irigoyen (1894–1967), Argentine film director
• María Irigoyen (born 1987), Argentine professional tennis player
• Martín Irigoyen (born 1977), Argentine musician, composer and one of the pioneers of the steampunk sound
• Matías de Irigoyen (1781–1839), Argentine soldier and politician
• Miguel de Irigoyen (1764–1822), Argentine soldier and police chief
• Roberto Irigoyen (before 1923 – after 1948), Argentine cinematographer
• William Irigoyen (born 1970), French journalist

• Iman (comics) (Diego Irigoyen), fictional superhero from DC Comics

• Bernardo de Irigoyen, Misiones, city in the province of Misiones, Argentina
• Bernardo de Irigoyen, Santa Fe, town (comuna) in the center-east of the province of Santa Fe, Argentina
• Yrigoyen (disambiguation) (also Yrigollen)