GSS may refer to:

• Garibaldi Secondary School, in Maple Ridge, British Columbia, Canada
• The Gifted Students' School (Iraq), in Baghdad
• Government Secondary School (disambiguation)
• Greenridge Secondary School, in Singapore
• Grimsby Secondary School, in Ontario, Canada
• GSS Institute of Technology, in Bangalore, India
• Gay Student Services, now GLBT Aggies, at Texas A&M University

• Global Standards Symposium
• Civic Alliance of Serbia (Serbian: Građanski Savez Srbije), a political party in Serbia
• Government Statistical Service, of the Government of the United Kingdom
• Israeli General Security Service, also known as Shin Bet
• Ghana Statistical Service, of the Government of Ghana

• General Social Survey
• Genome survey sequence
• Gerstmann–Sträussler–Scheinker syndrome
• Glutathione synthetase
• Granulomatous slack skin
• Gudjonsson suggestibility scale

• Grønlands Seminarius Sportklub, a Greenlandic sport club
• Gurpreet Singh Sandhu, an Indian footballer
• Panionios G.S.S., a Greek association football club

• Generic Security Services Application Program Interface, an application programming interface for programs to access security services
• Graph Style Sheets
• GSS Infotech, an Indian information technology company
• Graph-structured stack
• Galileo Sensor Station, in satellite navigation

• Croatian Mountain Rescue Service (Croatian: Gorska Služba Spašavanja)
• Ghost Shadows, a Chinese-American gang
• Global Supply Systems, a British cargo airline
• Good Samaritan Society, a Canadian Lutheran service organization
• Great Singapore Sale, an annual shopping event in Singapore
• Greek Sign Language
• Grupo Silvio Santos, a Brazilian holding company
• Guild of Servants of the Sanctuary, in the Church of England