Arredondo is a surname of Spanish origin. Notable people with the surname include:

• Claudio Arredondo (born 1962), Chilean actor
• Héctor Arredondo (1970–2014), Mexican actor
• Inés Arredondo (1928–1989), Mexican writer
• Isidoro Arredondo (1655–1702), Spanish painter
• Maria Arredondo (born 1985), Norwegian pop singer
• Ricardo Arredondo (painter) (1850–1911), Spanish painter
• Samuel Arredondo (born 2002), Korean-Mexican pop singer

• Carolina Arredondo (born 1986), Chilean politician and actress
• Arcelia Arredondo García (born 1957), Mexican politician
• Avelino Arredondo, 19th century Uruguayan assassin
• Ben Arredondo, American politician
• Carlos Arredondo, American anti-war activist
• Jesús Arredondo Velázquez (born 1964), Mexican politician
• José Joaquín de Arredondo (1768–1837), Spanish-Mexican soldier
• Nicolás Antonio de Arredondo (1726–1802), Spanish soldier and politician, fourth viceroy of Río de la Plata
• Manuel Arredondo y Pelegrín (1738–1822), Spanish judge, soldier and colonial administrator in Peru and Ecuador
• Salvador Arredondo Ibarra (born 1948), Mexican politician
• Sergio Arredondo (died 2018), Chilean death squad leader
• Victor A. Arredondo, Mexican politician

• Édgar Arredondo (born 1997), Mexican baseball player
• Eduardo Arredondo (born 1984), Mexican baseball player
• José Arredondo (born 1984), Dominican baseball pitcher
• Rojelio Arredondo (born 1950), American sport shooter
• Julián Arredondo (born 1988), Colombian cyclist
• Luis Arredondo (born 1952), Mexican judoka
• Nicolás Arredondo (boxer) (1950–1987), Mexican boxer
• René Arredondo (judoka) (born 1944), Mexican judoka
• René Arredondo (boxer) (born 1961), Mexican boxer, brother of Ricardo Arredondo (boxer) and Roberto Arredondo
• Ricardo Arredondo (boxer) (1949–1991), Mexican boxer, brother of René Arredondo (boxer) and Roberto Arredondo
• Valentín Arredondo (born 1989), Mexican footballer

• Alberto Arredondo (1912–1968), Cuban journalist and economist
• Oscar Arredondo (1918–2001), Cuban paleontologist and ornithologist
• Patricia Arrendondo (born 1945), Mexican-American counseling psychologist
• Pedro "Pete" Arredondo, chief of the Uvalde Consolidated Independent School District Police Department, 2020–2022