ACD may refer to:

• IATA airport code for Alcides Fernández Airport in Acandí, Chocó Department, Colombia

• ACD (telecommunications company), carrier and Internet Service Provider, headquartered in Lansing, Michigan
• ACD Systems, a computer software manufacturer
• Advanced Chemistry Development (ACD/Labs), a chemistry software company

• ACD San Marcial, a Spanish football team based in Lardero, La Rioja
• Adelaide College of Divinity, an Australian theological college
• African Congress of Democrats, a South African political party
• Arbeitsgemeinschaft der Christengemeinden in Deutschland (Association of Christian Churches in Germany)
• Asia Cooperation Dialogue, an international organization
• Asiatic Cavalry Division, a White Army unit that fought in the Russian Civil War
• Centre Right Alliance (Romania) (Romanian: Alianța de Centru Dreapta), a political alliance
• Australasian College of Dermatologists, a medical specialist college

• Arthur Conan Doyle, creator of Sherlock Holmes

• ACD (gene), protein encoded by the ACD gene
• α-Cyclodextrin, a glucose polymer
• Alveolar capillary dysplasia, disorder of the lung
• Anemia of chronic disease, form of anemia
• Aragonite compensation depth, a property of oceans
• Allergic contact dermatitis, form of contact dermatitis

• Activity-centered design, design based on how humans interact with technology
• Anti-collision device, on Indian railways
• Apple Cinema Display, a line of monitors
• Automatic call distributor, device that directs incoming phone calls
• Average call duration, average length of telephone calls

• ACD (album), a 1989 album by Half Man Half Biscuit
• Adjournment in contemplation of dismissal, court ruling to defer the disposition of a defendant's case
• Antecedent-contained deletion in grammar
• Activity cycle diagram, a systems modelling paradigm
• Autoregressive conditional duration, a class of models used in financial econometrics
• Kyode language (ISO 639-3 code), a Guang language of Ghana
• Australian Cattle Dog, a breed of herding dog