Madison Keys defeated Svetlana Kuznetsova in the final, 7–5, 7–6^(7–5) to win the women's singles tennis title at the 2019 Cincinnati Masters.

Kiki Bertens was the defending champion, but lost in the second round to Venus Williams.

Naomi Osaka retained the world No. 1 singles ranking after the tournament. Ashleigh Barty and Karolína Plíšková were also in contention for the top ranking.^[1]

This tournament marked Maria Sharapova's final WTA Tour-level victory before her retirement; she defeated Alison Riske in the first round before losing to Barty in the second round.

The top eight seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.

	Quarterfinals							Semifinals							Final
	1	Ashleigh Barty	5	6	6
		Maria Sakkari	7	2	0
								1	Ashleigh Barty	2	4
								WC	Svetlana Kuznetsova	6	6
	3	Karolína Plíšková	6	62	3
	WC	Svetlana Kuznetsova	3	77	6
															WC	Svetlana Kuznetsova	5	65
															16	Madison Keys	7	77
		Venus Williams	2	3
	16	Madison Keys	6	6
								16	Madison Keys	7	6
									Sofia Kenin	5	4
		Sofia Kenin	6	1	2
	2	Naomi Osaka	4	6	0r

	First round							Second round							Third round							Quarterfinals
								1	A Barty	6	6
	WC	M Sharapova	6	77				WC	M Sharapova	4	1
	WC	A Riske	3	64											1	A Barty	4	7	7
		C Garcia	61	1												A Kontaveit	6	5	5
	Q	I Świątek	77	6				Q	I Świątek	4	62
		A Kontaveit	79	6					A Kontaveit	6	77
	13	A Kerber	67	2																		1	A Barty	5	6	6
	9	A Sabalenka	6	6																			M Sakkari	7	2	0
		P Martić	1	4				9	A Sabalenka	6	6
		V Kužmová	3	1					S Zheng	4	3
		S Zheng	6	6											9	A Sabalenka	77	4	4
		M Sakkari	6	6												M Sakkari	64	6	6
		C Giorgi	3	0					M Sakkari	6	2	6
								6	P Kvitová	4	6	3

	First round							Second round							Third round							Quarterfinals
								3	Ka Plíšková	6	6
	LL	Y Wang	3	7	6			LL	Y Wang	1	3
	LL	M Puig	6	5	3										3	Ka Plíšková	7	6
	WC	B Pera	2	3											Q	R Peterson	5	4
	Q	V Kudermetova	6	6				Q	V Kudermetova	6	5	2
	Q	R Peterson	6	3	7			Q	R Peterson	2	7	6
	14	J Konta	3	6	5																	3	Ka Plíšková	6	62	3
	11	A Sevastova	63	77	4																	WC	S Kuznetsova	3	77	6
	WC	S Kuznetsova	77	64	6			WC	S Kuznetsova	4	79	6
		D Yastremska	6	6					D Yastremska	6	67	2
		C Wozniacki	4	4											WC	S Kuznetsova	6	6
		J Ostapenko	2	77	3										8	S Stephens	1	2
		Y Putintseva	6	63	6				Y Putintseva	6	4	3
								8	S Stephens	2	6	6

	First round							Second round							Third round							Quarterfinals
								5	K Bertens	3	6	64
		V Williams	7	6					V Williams	6	3	77
	Q	L Davis	5	2												V Williams	2	6	6
		K Siniaková	4	3												D Vekić	6	3	3
		D Vekić	6	6					D Vekić	6	7
		V Azarenka	6	1					V Azarenka	2	5
	12	B Bencic	4	0r																			V Williams	2	3
	16	M Keys	64	77	6																	16	M Keys	6	6
		G Muguruza	77	65	4			16	M Keys	6	6
	LL	B Strýcová	4	69					D Kasatkina	4	1
		D Kasatkina	6	711											16	M Keys	6	3	7
		E Alexandrova	6	6											4	S Halep	1	6	5
		C Suárez Navarro	4	1					E Alexandrova	6	5	4
								4	S Halep	3	7	6

	First round							Second round							Third round							Quarterfinals
								7	E Svitolina	6	6
		E Mertens	7	6					E Mertens	4	1
	WC	C McNally	5	0											7	E Svitolina	3	63
		S Kenin	6	78												S Kenin	6	77
		J Görges	4	66					S Kenin	6	6
	Q	Z Diyas	7	6				Q	Z Diyas	4	1
	LL	J Pegula	5	4																			S Kenin	6	1	2
	15	Q Wang	3	4																		2	N Osaka	4	6	0r
		S-w Hsieh	6	6					S-w Hsieh	711	6
	Q	O Jabeur	2	2				Q	J Brady	69	3
	Q	J Brady	6	6												S-w Hsieh	63	7	2
		A Sasnovich	6	4	6										2	N Osaka	77	5	6
	Q	A Sharma	1	6	1				A Sasnovich	63	6	2
								2	N Osaka	77	2	6

	First round							Qualifying competition
	1	Barbora Strýcová	77	3	6
		Kaia Kanepi	63	6	3
								1	Barbora Strýcová	2	1
									Rebecca Peterson	6	6
		Rebecca Peterson	6	7
	12	Margarita Gasparyan	1	5

	First round							Qualifying competition
	2	Zhang Shuai	4	65
		Kristýna Plíšková	6	77
									Kristýna Plíšková	1	4
								16	Lauren Davis	6	6
	WC	Kristie Ahn	6	67	2
	16	Lauren Davis	2	79	6

	First round							Qualifying competition
	3	Monica Puig	62	6	6
		Anastasia Potapova	77	1	4
								3	Monica Puig	2	1
								10	Veronika Kudermetova	6	6
	WC	Destanee Aiava	4	6	2
	10	Veronika Kudermetova	6	2	6

	First round							Qualifying competition
	4	Anastasia Pavlyuchenkova	1	65
		Zarina Diyas	6	77
									Zarina Diyas	64	77	6
								9	Jessica Pegula	77	63	4
		Mihaela Buzărnescu	3	65
	9	Jessica Pegula	6	77

	First round							Qualifying competition
	5	Kristina Mladenovic	2	5
		Magda Linette	6	7
									Magda Linette	6	3	4
									Jennifer Brady	2	6	6
		Jennifer Brady	1	6	6
	11	Jil Teichmann	6	1	2

	First round							Qualifying competition
	6	Wang Yafan	6	6
	WC	CoCo Vandeweghe	2	2
								6	Wang Yafan	4	6	4
								15	Iga Świątek	6	3	6
		Kateryna Kozlova	2	77	4
	15	Iga Świątek	6	60	6

	First round							Qualifying competition
	7	Alizé Cornet	65	3
		Andrea Petkovic	77	6
									Andrea Petkovic	3	0
								13	Ons Jabeur	6	6
	WC	Shelby Rogers	5	6	65
	13	Ons Jabeur	7	2	77

	First round							Qualifying competition
	Alt	Astra Sharma	6	6
		Viktorija Golubic	3	3
								Alt	Astra Sharma	6	6
								PR	Bethanie Mattek-Sands	4	4
	PR	Bethanie Mattek-Sands	6	6
	14	Elena Rybakina	3	2

• Main Draw
• Qualifying Draw