Serrano is a surname common in the Spanish, Portuguese, and Italian languages.
Notable people
- Amanda Serrano, Puerto Rican boxer
- Ana Serrano, artist
- Ana Serrano Redonnet, Argentine composer
- Andres Serrano, American photographer
- Antonio Serrano, Mexican film writer-director
- Antonio Serrano, Spanish long-distance runner
- Antonio Serrano, Peruvian football striker
- Bartolomé Serrano, Spanish long-distance runner
- Boni Serrano, Filipino veteran of the Korean War
- Carla Heredia Serrano, Ecuadorian chess player
- Cindy Serrano, Puerto Rican boxer
- Danny Vargas Serrano (born 1979), member of the Legislative Assembly of Costa Rica
- Dave Serrano (born 1964), American college baseball coach
- David Serrano Sobral (born 1986), Portuguese astrophysicist
- Eduardo Serrano (musician) (1911–2008), Venezuelan musician
- Eduardo Serrano (actor) (born 1942), Venezuelan actor
- Elba Serrano, Puerto Rican neuroscientist
- Emilia Serrano de Wilson, Spanish writer, journalist, feminist, traveler
- Eva Serrano, French gymnast
- Felix Serrano, American comic book artist
- Francho Serrano (born 2001), Spanish footballer
- Francisco J. Serrano, Mexican civil engineer and architect
- Francisco Serrano y Domínguez, Duke de la Torre, Spanish marshal and statesman
- Irma Serrano, Mexican actress
- Ismael Serrano, Spanish Singer/Songwriter
- J. Francisco Serrano Cacho, Mexican architect
- Jorge Serrano Elías, President of Guatemala
- José Enrique Serrano, Democrat, U.S. House of Representatives
- José Serrano (composer), Spanish composer of zarzuelas
- José António Serrano, Portuguese physician
- José Manuel Serrano, Spanish footballer
- José Mariano Serrano, Bolivian member of the Congress of Tucumán
- Joseph Serrano, Puerto Rican boxer
- Juan Serrano, sixteenth-century Portuguese navigator
- Juan Serrano (Flamenco), Spanish flamenco guitarist
- Juan René Serrano, Mexican archer
- Julian Serrano, Spanish-American chef
- María Isabel Prieto Serrano (born 1973), Spanish politician
- Marta Serrano, Spanish long-distance runner and a steeplechaser
- Mary J. Serrano, a writer, poet and translator
- Miguel Serrano, Chilean diplomat and writer
- Nestor Serrano, American actor
- Nina Serrano, American poet and storyteller
- Pedro Serrano (police officer), New York City police officer
- Pedro Serrano (sailor), sixteenth-century Spanish sailor
- Ramón Serrano Súñer, Spanish politician
- Roberto Serrano, American economist
- Rosana Serrano, Cuban rower
- Sebastià Serrano, Spanish linguist and author
Fictional characters
- Heris Serrano, the central character in the Familias Regnant books
- Inèz Serrano, one of the characters in the existentialist French play No Exit by Jean-Paul Sartre.