Sefton may refer to:

• Sefton, Merseyside, a village in Merseyside, England
  • Metropolitan Borough of Sefton, a metropolitan borough of Merseyside, England
• Sefton, New South Wales, a suburb of Sydney, Australia
• Sefton, New Zealand, a small settlement in New Zealand
• Sefton, a housing estate in Dún Laoghaire Borough, in County Dublin, Ireland
• Mount Sefton, a mountain close to Mount Cook in New Zealand's Southern Alps

• Sefton Brancker (1877–1930), Air Vice Marshal
• Sefton Delmer (1904–1979), journalist

• Allan Roy Sefton (1921–1989), Australian ornithologist and environmentalist
• Amanda Sefton, Marvel Comics character
• Ann Elizabeth Sefton (born 1936), Australian neurologist and educator
• Clyde Sefton (born 1951), cyclist
• Fred Sefton (1888–1976), basketball coach

• Sefton Coast, Site of special scientific interest
• Sefton (army horse), a horse (survivor of a terrorist bombing in 1982)
• Sefton (racehorse), winner of the 1878 Epsom Derby
• Sefton Metropolitan Borough Council, the governing body of the borough
• Earl of Sefton, part of the Peerage of Ireland
• Sefton, a cultivar of Agrostis capillaris (Common Bentgrass) developed in New Zealand

• 7552 Sephton, an asteroid