Schlick or Schlicke is a German surname. Notable people with the surname include:

• Moritz Schlick (1882–1936), German philosopher and the founding father of logical positivism and the Vienna Circle
• Arnolt Schlick (c. 1457–c. 1521), German organist and composer of the Renaissance
• Robert H. Von Schlick (1875–1941), German-born United States Army private
• Ernst Otto Schlick (1840–1913), German engineer
• Katherine Schlick Noe, Professor of Education at Seattle University
• Björn Schlicke (born 1981), German footballer
• Heinz Schlicke (1912–2006), German-born engineer and author
• The Counts von Schlick, who mined silver for coins named Joachimsthaler

• Schlick's approximation, an approximation of the BRDF of metallic surfaces
• Schlick, onomatopoeic slang for female masturbation
• Vito Schlickmann (1928–2023), Brazilian Roman Catholic prelate