San Juan del Río is a name shared by several towns and cities in Mexico:
- San Juan del Río, Querétaro, the largest and best known.
- San Juan del Río, Coahuila
- San Juan del Río, Durango
- San Juan del Río, Oaxaca
- San Juan del Río, former name of Rafael Delgado, Veracruz, prior to 1932