RKO refers to RKO Pictures, an American film company.
RKO may also refer to:
Organisations
- RKO General, holding company for General Tire and Rubber Company up to 1981
- RKO Radio Network, a subsidiary of RKO General
- Rutten Komt Op, a football team of Rutten, Flevoland
Other
- Reichskommissariat Ostland, Nazi-controlled Baltic territory in WWII
- Randal Keith Orton or Randy Orton, a WWE pro wrestler
- his finishing move, the RKO, a jumping cutter
- Rated-RKO, his former wrestling team