Muscat is a fairly common surname among people of Maltese descent. The following people have the surname Muscat:

• Angelo Muscat (1930–1977), Maltese actor
• Brent Muscat (b. 1967), American rock guitarist
• Emma Muscat (b. 1999), Maltese singer and model, represented Malta in the Eurovision Song Contest 2022
• Jessika Muscat (b. 1989), Maltese singer and actress, represented San Marino in the Eurovision Song Contest 2018
• Mike Muscat (b. 1952), American actor

• Joseph Muscat (b. 1974), former Prime Minister of Malta
• Josie Muscat (b. 1943), Maltese politician

• James Muscat (b. 2002) American Baseball Player
• Alex Muscat (b. 1984), Maltese footballer
• Charles Muscat (1963–2011), Maltese footballer
• Kevin Muscat (b. 1973), Australian football coach
• Manny Muscat (b. 1984), Maltese-Australian footballer
• Mario Muscat (b. 1976), Maltese footballer
• Nicola Muscat (b. 1994), Maltese swimmer
• Richard Muscat (b. 1992), Australian motor-racing driver
• Rowen Muscat (b. 1991), Maltese footballer
• Zach Muscat (b. 1993), Maltese footballer

• John Nicholas Muscat (1735–c.1800), Maltese philosopher

• Ġużè Muscat Azzopardi (1853–1927), Maltese writer and lawyer
• Muskat