MacPherson or Macpherson is a surname, meaning "son of the parson" in Scottish Gaelic. Notable people with the surname include:

• Archie Macpherson (born 1937), Scottish football commentator
• Bruce MacPherson (field hockey), Canadian field hockey player
• Bryden Macpherson, Australian amateur golfer
• Duncan MacPherson, ice hockey player
• Gus MacPherson, Scottish footballer
• Jeff MacPherson, driver in the CART Championship Car series
• Michelle MacPherson, Canadian swimmer

• Ben Macpherson (politician), Scottish politician
• C. B. Macpherson, Canadian academic
• Dean Macpherson, South African politician
• Hector Macpherson, Sr. (1875–1970), Canadian-American agricultural economics professor and politician
• Hector Macpherson, Jr. (1918–2015), American farmer and politician
• James Ian Macpherson, British lawyer and politician
• John Alexander MacPherson, Australian politician
• John MacPherson (governor of India), Scottish administrator in India
• John Thomas Macpherson (1872–1921), English politician
• Malcolm MacPherson (1904–1971), Scottish politician
• Murdoch MacPherson, Canadian politician
• Niall Macpherson, 1st Baron Drumalbyn, Scottish politician
• Nicholas Macpherson, British civil servant
• Thomas Macpherson, 1st Baron Macpherson of Drumochter (1888–1965), Scottish politician

• Ben Macpherson, Australian musician
• Christina Macpherson, Australian behind Waltzing Matilda
• Fraser MacPherson, Canadian jazz musician
• Greg MacPherson, Canadian singer-songwriter
• Graham MacPherson, better known as Suggs, the lead singer of the English band Madness
• Jim Macpherson, United States percussionist
• Linda Lizotte-MacPherson, Canadian public servant
• Sandy MacPherson, Canadian theatre organist
• Donald Macpherson BEM was a Scottish bagpipe player, and one of the most successful competitive solo pipers of all time

Gillie Mc Pherson, singer songwriter from Belfast, Zoë Mc Pherson, French electronic musician

• James Alan McPherson, American essayist
• James Macpherson, Scottish poet
• Jay Macpherson, Canadian poet

• Daniel MacPherson, Australian actor and television presenter
• Don Macpherson, Canadian journalist
• Duncan Macpherson, Canadian editorial cartoonist
• Elle Macpherson, Australian supermodel and actress
• Gordon Macpherson, Founder of Macpherson Menswear – Palmerston North, New Zealand.
• Hector Macpherson (1851–1924), Scottish journalist and writer
• Jeanie MacPherson(1886–1946), American silent actress, writer and director
• Malcolm MacPherson (1943–2009), American journalist and author
• Myra MacPherson, American journalist and author
• Richard MacPherson, American actor

• Alexander Macpherson, English architect
• Cluny MacPherson, Newfoundland medical doctor and inventor of the gas mask
• Colin MacPherson, Scottish Roman Catholic Bishop of Argyll and the Isles from 1968 to 1990
• Donald Macpherson (disambiguation), several people
• Earle S. MacPherson, the Ford engineer who developed the MacPherson strut in the 1940s
• Ewen MacPherson of Cluny, Scottish Jacobite
• Fiona Macpherson, FRSE, MAE, Scottish Professor of Philosophy and Director of the Centre for the Study of Perceptual Experience, University of Glasgow
• Hector Macpherson (astronomer) (1888–1956), Scottish clergyman and astronomer, son of Hector C. Macpherson
• Ian MacPherson, Canadian historian
• Jamie Macpherson, Scottish outlaw, famed for his lament
• John Macferson, early 18th-century English pirate
• Sir Macpherson Robertson, Australian philanthropist and entrepreneur
• Robert Macpherson (disambiguation), multiple people
• Colonel Ronald MacPherson or Ranald MacPherson (1817–1869), architect and colonial administrator
• Colonel Tommy Macpherson, British army officer
• Sir William Macpherson, High Court Judge in England

• Anya MacPherson, fictional character in Degrassi: The Next Generation

• Clan Macpherson, a Scottish clan
• The Macpherson Report, into the death of Black British teenage Stephen Lawrence
• MacPherson v. Buick Motor Co.
• MacPherson strut, a car suspension system
• MacPherson, Singapore
• Macpherson Stadium (disambiguation)
• McPherson (disambiguation)