The Second Canadian Ministry was the cabinet chaired by Prime Minister Alexander Mackenzie. It governed Canada from 7 November 1873 to 8 October 1878, including the last two months of the 2nd Canadian Parliament as well as all of the 3rd. The government was formed by the Liberal Party of Canada.

• Prime Minister
  • 7 November 1873 – 17 October 1878: Alexander Mackenzie
• Minister of Agriculture
  • 7 November 1873 – 15 December 1876: Luc Letellier de St-Just
  • 15 December 1876 – 26 January 1877: Isaac Burpee (Acting)
  • 26 January 1877 – 17 October 1878: Charles Alphonse Pantaléon Pelletier
• Minister of Customs
  • 7 November 1873 – 17 October 1878: Isaac Burpee
• Minister of Finance
  • 7 November 1873 – 17 October 1878: Richard John Cartwright
• Superintendent-General of Indian Affairs
  • 7 November 1873 – 17 October 1878: The Minister of the Interior (Ex officio)
  • 7 November 1873 – 7 October 1876: David Laird
  • 7 October 1876 – 24 October 1876: Richard William Scott (Acting)
  • 24 October 1876 – 17 October 1878: David Mills
• Minister of Inland Revenue
  • 7 November 1873 – 8 July 1874: Télesphore Fournier
  • 8 July 1874 – 9 November 1876: Félix Geoffrion
  • 9 November 1876 – 8 June 1877: Rodolphe Laflamme
  • 8 June 1877 – 8 October 1877: Joseph-Édouard Cauchon
  • 8 October 1877 – 17 October 1878: Wilfrid Laurier
• Minister of the Interior
  • 7 November 1873 – 7 October 1876: David Laird
  • 7 October 1876 – 24 October 1876: Richard William Scott (Acting)
  • 24 October 1876 – 17 October 1878: David Mills
• Minister of Justice
  • 7 November 1873 – 1 June 1874: Antoine-Aimé Dorion
  • 1 June 1874 – 8 July 1874: Albert James Smith (Acting)
  • 8 July 1874 – 19 May 1875: Télesphore Fournier
  • 19 May 1875 – 8 June 1877: Dominick Edward Blake
  • 8 June 1877 – 17 October 1878: Rodolphe Laflamme
• Attorney General of Canada
  • 7 November 1873 – 17 October 1878: The Minister of Justice (Ex officio)
    • 7 November 1873 – 1 June 1874: Antoine-Aimé Dorion
    • 1 June 1874 – 8 July 1874: Sir Albert James Smith (Acting)
    • 8 July 1874 – 19 May 1875: Télesphore Fournier
    • 19 May 1875 – 8 June 1877: Dominick Edward Blake
    • 8 June 1877 – 17 October 1878: Rodolphe Laflamme
• Leader of the Government in the Senate
  • 7 November 1873 – 14 December 1876: Luc Letellier de St-Just
  • 14 December 1876 – 17 October 1878: Richard William Scott
• Minister of Marine and Fisheries
  • 7 November 1873 – 17 October 1878: Albert James Smith
• Minister of Militia and Defence
  • 7 November 1873 – 30 September 1874: William Ross
  • 30 September 1874 – 21 January 1878: William Berrian Vail
  • 21 January 1878 – 17 October 1878: Alfred Gilpin Jones
• Postmaster General
  • 7 November 1873 – 19 May 1875: Donald Alexander Macdonald
  • 19 May 1875 – 9 October 1875: Télesphore Fournier
  • 9 October 1875 – 17 October 1878: Lucius Seth Huntington
• President of the Privy Council
  • 7 November 1873 – 20 January 1874: Alexander Mackenzie (acting)
  • 20 January 1874 – 9 October 1875: Lucius Seth Huntington
  • 9 October 1875 – 7 December 1875: Alexander Mackenzie (acting)
  • 7 December 1875 – 8 June 1877: Joseph-Édouard Cauchon
  • 8 June 1877 – 18 January 1878: Edward Blake
  • 18 January 1878 – 17 October 1878: Alexander Mackenzie (acting)
• Minister of Public Works
  • 7 November 1873 – 17 October 1878: Alexander Mackenzie
• Receiver General
  • 7 November 1873 – 17 October 1878: Thomas Coffin
• Secretary of State of Canada
  • 7 November 1873 – 9 January 1874: David Christie
  • 9 January 1874 – 17 October 1878: Richard William Scott
• Registrar General of Canada
  • 7 November 1873 – 17 October 1878: The Secretary of State of Canada (Ex officio)
    • 7 November 1873 – 9 January 1874: David Christie
    • 9 January 1874 – 17 October 1878: Richard William Scott
• Minister without Portfolio
  • 7 November 1873 – 14 February 1874: Dominick Edward Blake
  • 7 November 1873 – 9 January 1874: Richard William Scott

• Government of Canada. "Second Ministry". Guide to Canadian Ministries since Confederation. Privy Council Office. Archived from the original on 21 January 2017. Retrieved 1 July 2010.