Guidi is an Italian surname shared by several notable people:

• Alessandro Pier Guidi (born 1983), racing driver from Italy
• Angela Maria Guidi Cingolani (1896–1991), Italian politician
• Angelo Guidi (1888–1953), Italian racing cyclist
• Antonio Guidi (1927–2013), Italian actor and voice actor
• Antonio Guidi (born 1945), Italian politician
• Carlo Alessandro Guidi (1650–1712), Italian lyric poet
• Chen Guidi (born 1942), Chinese writer from Huaiyuan county, Anhui
• Diego Guidi (born 1981), Argentine retired footballer
• Domenico Guidi (1625–1701), Italian sculptor
• Dominique Guidi (born 1996), French professional footballer
• Donna Rachele Guidi (1890–1979), wife of Italian dictator Benito Mussolini
• Emanuele Guidi (born 1969), Sammarinese archer
• Fabrizio Guidi (born 1972), Italian cyclist
• Federica Guidi (born 1969), Italian businesswoman and the former Minister of Economic Development
• Gianluca Guidi (born 1968), Italian rugby union coach and former player
• Gina Guidi (born 1962), American professional female boxer
• Giovanni Francesco Guidi di Bagno, Italian cardinal, brother of cardinal Nicola and nephew of cardinal Colonna
• Giovanni di ser Giovanni Guidi (1406–1486), Italian painter, brother of Masaccio
• Guidarino Guidi (1922–2003), Italian film actor and director
• Guido Guidi (fl. 20th century), Italian comic book artist and penciller
• Guido Guidi (photographer) (born 1941), Italian photographer
• Guido Buffarini Guidi (1895–1945), Italian politician active during the Second World War
• Ignazio Guidi (1844–1935), Italian orientalist
• Jennifer Guidi (born 1972), American artist
• Juan Héctor Guidi (1930–1973), Argentine footballer
• Leonardo Guidi (born 1974), Italian racing cyclist
• Nicholas Guidi (born 1983), Italian football defender
• Nicola Guidi di Bagno (1583–1663), titular archbishop of Atenia, bishop of Senigallia, and cardinal
• Osvaldo Guidi (1964–2011), Italian cinema, theater and television actor, and a dramaturge and theater director
• Peter Guidi (1949–2018), American jazz musician
• Scipione Guidi (1884–1966), Italian violinist
• Tommaso di Giovanni di Simone Guidi Masaccio (1401-1428), Italian leading painter
• Valentina Guidi Ottobri (born 1988), Italian art curator
• Virgilio Guidi (1891–1984), Italian artist and writer

• Guidi (family)
• Guido
• Casa Guidi
• Cerreto Guidi, in the Metropolitan City of Florence
• Poppi Castle