Glucokinase regulator is a protein that in humans is encoded by the GCKR gene. [5]
Function
This gene encodes a protein belonging to the GCKR subfamily of the SIS (sugar isomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000084734 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059434 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Glucokinase regulator". Retrieved 2018-09-21.
Further reading
- Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P (May 2003). "Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians". Diabetologia. 46 (5): 704–11. doi:10.1007/s00125-003-1083-y. PMID 12739015.
- Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P (May 2003). "Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians". Diabetologia. 46 (5): 704–11. doi:10.1007/s00125-003-1083-y. PMID 12739015.
- Brocklehurst KJ, Davies RA, Agius L (March 2004). "Differences in regulatory properties between human and rat glucokinase regulatory protein". Biochem. J. 378 (Pt 2): 693–7. doi:10.1042/BJ20031414. PMC 1223974. PMID 14627435.
- Køster B, Fenger M, Poulsen P, Vaag A, Bentzen J (December 2005). "Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population". Diabet. Med. 22 (12): 1677–82. doi:10.1111/j.1464-5491.2005.01700.x. PMID 16401311. S2CID 20786263.
- Heredia VV, Carlson TJ, Garcia E, Sun S (December 2006). "Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations". J. Biol. Chem. 281 (52): 40201–7. doi:10.1074/jbc.M607987200. PMID 17082186.
- García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA (February 2007). "Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity". Diabetologia. 50 (2): 325–33. doi:10.1007/s00125-006-0542-7. PMID 17186219.
- Ellard S, Thomas K, Edghill EL, Owens M, Ambye L, Cropper J, Little J, Strachan M, Stride A, Ersoy B, Eiberg H, Pedersen O, Shepherd MH, Hansen T, Harries LW, Hattersley AT (November 2007). "Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young". Diabetologia. 50 (11): 2313–7. doi:10.1007/s00125-007-0798-6. PMID 17828387.
- Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O (January 2008). "The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes". Diabetologia. 51 (1): 70–5. doi:10.1007/s00125-007-0865-z. PMID 18008060.
- Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O (January 2008). "The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes". Diabetologia. 51 (1): 70–5. doi:10.1007/s00125-007-0865-z. PMID 18008060.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.