Cena was the main meal of the day in ancient Rome.

Cena may also refer to:

• John Cena, an American professional wrestler and actor
• Marcone Cena, a Brazilian footballer

• Cena, Jelgava Municipality, a village in Latvia
• Cena Parish, an administrative unit of Jelgava Municipality in the Semigallia region of Latvia.
• Cena River, a river in Latvia

• The Spanish and Italian word for dinner
• The Portuguese word for scene
• The Czech and Slovak word for Price

• Cena (sign language), a language used by deaf inhabitants of Várzea Queimada, Brazil
• Cena N641, a bomb detection dog in the US Marines

• Cene (disambiguation)