Burden of proof may refer to:

• Burden of proof (law)
• Burden of proof (philosophy)

• The Burden of Proof (1918 film), a silent American film starring Marion Davies
• The Burden of Proof (Barlow novel), a 1968 novel by James Barlow
• The Burden of Proof (Turow novel), a 1990 novel by Scott Turow
• The Burden of Proof (miniseries), a 1992 TV series based on the Turow novel
• "Burden of Proof" (CSI episode)
• Burden of Proof, a CNN legal analysis show
• Burden of Proof (TV series), an upcoming American true crime documentary miniseries

• Burden of Proof (Soft Machine Legacy album), 2013
• Burden of Proof (Bob Schneider album), 2013
• Burden of Proof (Benny the Butcher album), 2020