The following is a list of notable births in 2000.

• January 1 – Ice Spice, American rapper^[1]
• January 8 - Noah Cyrus, American singer and actress
• January 10 – Reneé Rapp, American actress and singer^[2]
• January 20 – Selemon Barega, Ethiopian long-distance runner^[3]
• January 27 – Bailey Zimmerman, American singer and songwriter^[4]
• February 10 – Yara Shahidi, American actress, model and producer^[5]
• February 23 – Femke Bol, Dutch hurdler and sprinter^[6]
• March 9 – Khaby Lame, Senegalese-Italian social media personality^[7]
• March 14 – Chrisean Rock, American rapper and reality television personality^[8]
• March 21 – Jace Norman, American actor^[9]
• March 25 – Jadon Sancho, English footballer^[10]
• March 27 – Halle Bailey, American singer and actress^[11]
• March 31 – Ruby Cruz, American actress^[12]
• April 12 – David Hogg, American gun control activist^[13]
• April 23 – Chloe Kim, American snowboarder^[14]

• May 1 – Rema, Nigerian musician and songwriter^[15]
• May 2 – Tom Dean, British swimmer^[16]
• May 28 – Phil Foden, English footballer^[17]
• May 30 - Jared S. Gilmore, American actor ans streamer
• May 31 – Gable Steveson, American wrestler^[18]
• June 17 – Odessa A'zion, American actress^[19]
• July 6 – Zion Williamson, American basketball player^[20]
• July 21 – Erling Haaland, Norwegian footballer^[21]
• August 17 – Lil Pump, American rapper^[22]

• September 23 – Kalani Hilliker, American dancer and actress^[23]
• September 28 - Frankie Jonas, American singer and actor
• October 5 – Addison Rae, American social media personality and dancer^[24]
• October 9 – Harrison Burton, American race car driver
• October 11 – Adin Ross, American online streamer^[25]
• October 30 – Jeffery Xiong, American chess prodigy^[26]
• October 31 – Willow Smith, American singer and actress^[27]
• November 10 – Mackenzie Foy, American actress and model^[28]
• November 21 – Isabel May, American actress^[29]
• November 22 – Auliʻi Cravalho, American actress and singer^[30]
• November 22 – Baby Ariel, American social media personality^[31]
• December 18 – Jayden Daniels, American football player^[32]
• December 22 – Joshua Bassett, American actor and singer^[33]