In enzymology, a benzaldehyde dehydrogenase (NADP+) (EC 1.2.1.7) is an enzyme that catalyzes the chemical reaction

benzaldehyde + NADP⁺ + H₂O benzoate + NADPH + 2 H⁺

The 3 substrates of this enzyme are benzaldehyde, NADP⁺, and H₂O, whereas its 3 products are benzoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzaldehyde:NADP+ oxidoreductase. Other names in common use include NADP+-linked benzaldehyde dehydrogenase, and benzaldehyde dehydrogenase (NADP+). This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation.

• GUNSALUS CF, STANIER RY, Gunsalus IC (1953). "THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID III. : Fractionation and Properties of the Soluble Enzymes". J. Bacteriol. 66 (5): 548–53. PMC 317432. PMID 13108854.
• Stachow CS, Stevenson IL, Day D (1967). "Purification and properties of nicotinamide adenine dinucleotide phosphate-specific benzaldehyde dehydrogenase from Pseudomonas". J. Biol. Chem. 242 (22): 5294–300. PMID 4383635.