Defending champion Lloyd Glasspool and his partner Julian Cash defeated Jiří Lehečka and Jakub Menšík in the final, 6–3, 6–7^(2–7), [10–6] to win the men's doubles tennis title at the 2025 Brisbane International.^[1]

Glasspool and Jean-Julien Rojer were the reigning champions,^[2][3] but Rojer chose to compete in Hong Kong instead.

All seeds received a bye into the second round.

	Semifinals							Final
	5	Julian Cash Lloyd Glasspool	w/o
	Alt	Rinky Hijikata Jason Kubler
								5	Julian Cash Lloyd Glasspool	6	62	[10]
									Jiří Lehečka Jakub Menšík	3	77	[6]
		Jiří Lehečka Jakub Menšík	7	6
		Nicolás Jarry Giovanni Mpetshi Perricard	5	2

	First round							Second round							Quarterfinals							Semifinals
								1	N Mektić M Venus	6	3	[10]
		A Erler A Mies	4	77	[8]			WC	N Djokovic N Kyrgios	2	6	[8]
	WC	N Djokovic N Kyrgios	6	64	[10]										1	N Mektić M Venus	6	3	[3]
		S Balaji MÁ Reyes-Varela	4	2											5	J Cash L Glasspool	4	6	[10]
		M Guinard A Rinderknech	6	6					M Guinard A Rinderknech	6	4	[10]
								5	J Cash L Glasspool	4	6	[12]
																						5	J Cash L Glasspool	w/o
																						Alt	R Hijikata J Kubler
								Alt	R Hijikata J Kubler	6	6
		RC Bollipalli R Haase	77	3	[10]				RC Bollipalli R Haase	4	2
		G Escobar J-P Smith	64	6	[6]										Alt	R Hijikata J Kubler	2
		R Arneodo A Cazaux	4	5											7	A Krajicek R Ram	3r
		C Harrison M Willis	6	7					C Harrison M Willis	2	4
								7	A Krajicek R Ram	6	6

	First round							Second round							Quarterfinals							Semifinals
								8	N Barrientos S Gillé	3	4
	WC	C O'Connell J Thompson	6	3	[6]				J Lehečka J Menšík	6	6
		J Lehečka J Menšík	4	6	[10]											J Lehečka J Menšík	6	3	[10]
		V Cornea M Navone	6	4	[10]										3	N Lammons J Withrow	3	6	[6]
		G Jacq O Luz	2	6	[6]				V Cornea M Navone	4	64
								3	N Lammons J Withrow	6	77
																							J Lehečka J Menšík	7	6
																							N Jarry G Mpetshi Perricard	5	2
								6	J Murray J Peers	77	65	[7]
		N Jarry G Mpetshi Perricard	6	77					N Jarry G Mpetshi Perricard	65	77	[10]
	Alt	T Schoolkate A Walton	1	65												N Jarry G Mpetshi Perricard	w/o
		A Michelsen A Tabilo	3	2												J Duckworth A Vukic
		J Duckworth A Vukic	6	6					J Duckworth A Vukic	66	6	[10]
								2	H Heliövaara H Patten	78	4	[8]

• Main draw